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Alcohol-and opioid-dependent patientsincluding those taking REVIAshould be monitored for the development of depression or suicidal thinkingFamilies and caregivers of patients being treated with REVIA should be alerted to the need to monitor patients for the emergence of symptoms of depression or suicidalityand to report such symptoms to the patient’s healthcare provider.

In the clinical studiestreatment with REVIA supported abstinenceprevented relapse and decreased alcohol consumptionIn the uncontrolled studythe patterns of abstinence and relapse were similar to those observed in the controlled studiesREVIA was not uniformly helpful to all patientsand the expected effect of the drug is a modest improvement in the outcome of conventional treatment.

REVIA does not interfere with thin-layergas-liquidand high pressure liquid chromatographic methods which may be used for the separation and detection of morphinemethadone or quinine in the urineREVIA may or may not interfere with enzymatic methods for the detection of opioids depending on the specificity of the testPlease consult the test manufacturer for specific details.

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naltrexone differs in structure from oxymorphone in that the methyl group on the nitrogen atom is replaced by a cyclopropylmethyl group.

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